Did vaccination slow the spread of bluetongue in France

摘要: Vaccination is one of the most efficient ways to control spread infectious diseases. Simulations are now widely used assess how vaccination can limit disease as well mitigate morbidity or mortality in susceptible populations. However, field studies investigating much vaccines decrease velocity epizootic wave-fronts during outbreaks rare. This study aimed at effect on propagation bluetongue, a vector-borne ruminants. We data from 2008 bluetongue virus serotype 1 (BTV-1) southwest France. As was newly introduced this area, natural immunity livestock absent. allowed determination role changing while accounting for environmental factors that possibly influenced it. The average estimated across country despite restriction animal movements 5.4 km/day, which very similar 8 France also context restrictions movements. significantly reduced BTV-1. In comparison municipalities with no vaccine coverage, BTV-1 decreased by 1.7 km/day immunized animals. For first time, has been quantified using real whilst known modify spread. Our findings emphasize importance limiting landscape. Finally, factors, specifically those related vector abundance and activity, were found be good predictors spread, indicating these variables need adequately accounted when evaluating