Epidermal growth factor receptor protein overexpression and gene amplification are associated with aggressive biological behaviors of esophageal squamous cell carcinoma.

摘要: Alterations of the epidermal growth factor receptor (EGFR), including overexpression or gene mutations, contribute to malignant transformation human epithelial cells. The aim this study was assess EGFR amplification in esophageal squamous cell carcinoma (ESCC) tissue samples and investigate their correlations with biological behaviors. Tissue specimens from 56 patients surgically resected ESCC were obtained for immunohistochemical analysis expression fluorescence situ hybridization amplification. data statistically analyzed determine associations patient clinicopathological survival data. overexpressed 30 (53.6%) associated poor tumor differentiation (P=0.047). detected 13 cases (23.2%) advanced pathological stage (P=0.042) lymph node metastasis (P=0.002). univariate identified no association between overall (OS) patients. By contrast, predicted prognosis (P=0.031), while multivariate revealed a marginal statistical significance OS (P=0.056). increased copy number common events contributed behaviors, dedifferentiation metastasis. may therefore be useful predicting ESCC.