Pathological significance of epidermal growth factor receptor expression and amplification in human gliomas
作者： Li-li Zhao , Kan-lun Xu , Shan-wei Wang , Bai-lai Hu , Li-rong Chen
DOI: 10.1111/J.1365-2559.2012.04354.X
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摘要: Zhao L-l, Xu K-l, Wang S-w, Hu B-l & Chen L-r (2012) Histopathology 61, 726–736 Pathological significance of epidermal growth factor receptor expression and amplification in human gliomas Aims: To investigate (EGFR) gliomas to assess their association with survival. Methods results: Immunohistochemistry fluorescence in-situ hybridization were performed analyse EGFR status 158 cases primary glioma. Kaplan–Meier survival Cox regression analyses the prognosis patients. Overexpression variant III (EGFRvIII) found 102 (64.6%) 47 (29.7%), respectively. was significantly correlated World Health Organization (WHO) grade Karnofsky performance score (KPS) (both P < 0.05). Expression EGFRvIII WHO grade, gender, age, KPS (all 46 (29.1%), overexpression multifactor analysis showed that an independent unfavourable prognostic for at all ages, patients older than 60 years. Conclusions: associated those 60 years, The differing young old glioma its impact on needs further study.
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