A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells

摘要: As a validated therapeutic target in several human cancers, the EGF receptor (EGFR) provides focus to gain deeper insights into cancer pathophysiology. In this study, we report identification of naturally occurring and widely expressed EGFR isoform termed EGFRvA, which substitutes Ser/Thr-rich peptide for part carboxyl-terminal regulatory domain receptor. Intriguingly, EGFRvA expression relates more closely histopathologic grade poor prognosis patients with glioma. Ectopic cells conferred higher invasive capacity than vitro vivo. Mechanistically, stimulated STAT3, upregulated heparin-binding (HB-EGF). Reciprocally, HB-EGF phosphorylation at Y845 along generating positive feedback loop that may reinforce function. The significance was reinforced by findings it is attenuated miR-542-5p, microRNA known tumor suppressor. Taken together, our define newfound as key theranostic molecule.