EGF receptor in neoplasia and metastasis.

摘要: EGFR is a member of the tyrosine kinase family cell surface receptors with wide range expression throughout development and in variety different types. The receptor can transmit signals to cells: i) upon interaction ligands such as EGF, TGFα, amphiregulin or heparin binding ii) truncation mutation extracellular and/or intracellular domains, iii) amplification basal activity (in absence ligand) through cooperation other cellular signaling pathways nuclear events (e.g. v-erbA). activated exert pleiotropic functions on cells, depending their tissue origin state differentiation. Under certain conditions it also contribute neoplasia metastases. Such exist aberrant receptor/ligand activation wrong cell; at time; amounts). Aberrant signalling occur constitutive activation. Oncogenic potential has been demonstrated experimental animals. implicated human cancer, where may both initiation (glioblastoma) progression (epithelial tumors) disease. influence key steps processes tumor invasion dissemination. Involvement spread indicate use this target for antimetastatic therapy.