Convergence of EGF Receptor and Src Family Signaling Networks in Cancer

摘要: EGF receptor (EGFR) and c-Src are tyrosine kinases of the non-receptor classes, respectively, that which frequently co-overexpressed or co-activated in multiple human cancers, including those breast, prostate, lung, colon. Most these cancers express non-mutated forms each kinase, overexpression either is weakly non-oncogenic. However, When co-overexpressed, however, they exhibit profound synergism up-regulates many neoplastic processes, cell proliferation, survival, metastasis. This dependent upon greatly enhanced by physical association between ligand-stimulated EGFR, leads to activation both kinases, phosphorylation EGFR c-Src, substrates. Non-EGFR ligands, such as agonists for G-protein coupled receptors cytokine receptors, also induce subsequent oncogenic consequences this interaction. Because their important roles etiology progression a broad spectrum represent signaling molecules ripe combinatorial therapeutic targeting.