Myocardial disease in human immunodeficiency virus (HIV) infection: a review

摘要: Heart muscle disease is the most important cardiovascular manifestation of HIV infection and likely to become even more prevalent as infected patients live longer. This may present myocarditis, dilated cardiomyopathy or isolated left right ventricular dysfunction. Myocardial involvement in multifactorial arise a result myocardial invasion with itself, opportunistic infections, viral autoimmune response infection, drug-related cardiac toxicity, nutritional deficiencies, prolonged immunosuppression. Both adults children are affected severity ranging from incidental microscopic inflammatory findings at autopsy clinically significant chronic It associated poor prognosis, results symptomatic heart failure up 5% patients. Clinical pathological studies pre-HAART era show 30% prevalence AIDS. The introduction highly active antiretroviral therapy (HAART) regimens has substantially modified course by lengthening survival improving quality life HIV-infected There also good evidence that HAART significantly reduces incidence manifestations infection. By preventing infections reducing have reduced HIV-associated almost 7-fold era. however only available minority individuals areas world period still apply. In this review, aetiopathogenesis presentation related were reviewed measures taken improve discussed.