NOS gene transfer inhibits expression of cell cycle regulatory molecules in vascular smooth muscle cells
作者： Ram V. Sharma , Enqing Tan , Shengyun Fang , Milind V. Gurjar , Ramesh C. Bhalla
DOI: 10.1152/AJPHEART.1999.276.5.H1450
关键词:
摘要: The mechanisms of nitric oxide (NO)-mediated inhibition vascular smooth muscle (VSM) cell proliferation are still obscure. Cyclins A and E in association with cyclin-dependent kinase 2 (cdk2) serve as positive regulators for mammalian cycle progression through the G1/S checkpoint subsequent proliferation. Therefore, we have tested effect adenovirus-mediated transfection endothelial synthase (eNOS) gene into guinea pig coronary VSM cells on platelet-derived growth factor (BB homodimer) (PDGF-BB)-stimulated expression regulatory molecules. Transfection eNOS significantly inhibited (P < 0.05) [3H]thymidine incorporation DNA response to PDGF-BB stimulation compared lacZ-transfected control cells. transfer PDGF-BB-induced proliferating nuclear antigen (PCNA) cyclin ce...
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