Sensitization and tolerance.

摘要: The mechanisms responsible for sensitization, in particular within the gastrointestinal tract, are IgE-mediated as well of a non-IgE-mediated, immunological origin. phenomenon that is opposite sensitization maintenance tolerance and exemplified by 'oral tolerance'. cytokines transforming growth factor beta interferon gamma have been shown to be key immunoregulatory oral tolerance. A new experimental model eosinophilic allergic gastroenteritis has developed with use encapsulated dietary antigen. was used mice genetic deletions eosinophil chemokine eotaxin or cytokine IL-5, demonstrating importance eotaxin. In clinical allergy research, major question explain global increase asthma allergy. 'hygiene hypothesis' states lack maturation infant immune system from T helper 2 1 type response may caused less microbial stimulation Western societies. Several lines data support this hypothesis. However, apart constitution individual, breastfeeding infancy most important single determinant development