Age of red blood cells and transfusion in critically ill patients

摘要: Red blood cells (RBC) storage facilitates the supply of RBC to meet clinical demand for transfusion and avoid wastage. However, is associated with adverse changes in erythrocytes their preservation medium. These are responsible functional alterations accumulation potentially injurious bioreactive substances. They also may have clinically harmful effects especially critically ill patients. The consequences lesions, however, remain a matter persistent controversy. Multiple retrospective, observational, single-center studies reported heterogeneous conflicting findings about effect duration on morbidity and/or mortality trauma, cardiac surgery, intensive care unit Describing details this controversy, review not only summarizes current literature but highlights equipoise that currently exists regard use short versus standard (extended) red patients supports need large, randomized, controlled trials evaluating impact transfusing fresh (short storage) older (extended