Mutation-selection balance accounting for genetic variation for viability in Drosophila melanogaster as deduced from an inbreeding and artificial selection experiment.

摘要: We carried out an experiment of inbreeding and upward artificial selection for egg-to-adult viability in a recently captured population Drosophila melanogaster, as well computer simulations the experimental design, order to obtain information on nature genetic variation this important fitness component. The depression was linear with rate 0.70 ± 0.11% initial mean per 1% increase coefficient, realized heritability 0.06 ± 0.07. compared empirical observations response assuming balance between occurrence partially recessive deleterious mutations their elimination by selection. Our results suggest that model mutation-selection realistic mutational parameters can explain natural studied. Several models are incompatible some be discarded. Mutational low large average effect highly gene action, others high small close additive compatible all observations.