Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines

摘要: Hyaluronan and hyaluronidases have been proposed to be involved in tumor angiogenesis invasion. Three hyaluronidases, HYAL1, HYAL2 HYAL3, are located at the chromosomal region 3p21. In most small cell lung cancer (SCLC) lines 3p21 is part of a homozygote or heterozygote deletion. Gliomas known exist hyaluronan rich environment express high levels receptor CD44. panel SCLC glioma expression HYAL3 mRNA was examined. It observed that differed their ability splice out retained intron 5' UTR HYAL1 mRNA. A correlation seems between end general hyaluronidase activity. one line substantial activity abolished by immunoprecipitation Hyal1, which strongly indicates Hyal1 principal hyaluornidase examined lines. During severe hypoxia significant reduction both protein found. These results support theory involvement angiogenic invasive front tumors.