Glioma and Extracellular Matrix

摘要: Invasion of glioma cells into brain tissue involves a multitude molecular interactions invading with host and the surrounding extracellular matrix (ECM). The ECM is complex structure composed proteoglycans glycoproteins glial neuronal origin, which largely based on hyaluronic acid (HA) as central organizing glycosaminoglycan. It particularly rich in different carbohydrate epitopes undergoes developmental shift around synaptogenesis terminal maturation. Glioma do not only bind to components via specific receptors are highly expressed their surfaces but they actively shape by secreting constituents ECM-modulating enzymes like proteases, glycosidases, or sulfatases, thus creating permissive environment. Proteomic approaches have shown that individual secretomes can vary composition. This mutual glioma–host–ECM interaction, also microvasculature brain, contributes devastating nature tumors, because it enables malignant pave way parenchyma. normal well glioma-derived makes challenging identify entry points for successful therapeutic treatment. First attempts targeting technological change biomechanical properties promising need more time.