Predictive value and clinical significance of myenteric plexitis in Crohn's disease.

摘要: Background: Recurrence of Crohn's disease (CD) after ileal or colonic resection is common. Myenteric plexitis in the proximal margin an ileocolonic CD specimen may indicate ongoing pathology that relates to recurrence. We assessed risk factors for myenteric plexitis, effect on clinical recurrence, and whether preoperative medical therapies affect intensity plexitis. Methods: Ileocolonic specimens from 99 patients with were histologically scored presence severity plexitis. was correlated immunosuppressive therapy before index surgery. Univariate multivariate analyses performed identify predictive plexitis. Results: Myenteric present 43% 85% cases affected resected segments CD, respectively. Patients a previous more likely have than those no (odds ratio [OR] 3.5, 95% confidence interval [CI] 1.21–10.15, P = 0.02), greater duration less (OR 0.68, CI 0.48–0.96, 0.03). Preoperative not associated lesser incidence Twelve 40 (30%) 9 54 (16%) without subsequently developed recurrence (median 10 months; 0.17). Conclusions: Previous resections shorter are CD. The prognostic value postoperative stratification remain be prospectively established. (Inflamm Bowel Dis 2009)