Acute effects of nasal continuous positive airway pressure on 24-hour blood pressure and catecholamines in patients with obstructive sleep apnea.

摘要: To assess the acute effects of nasal continuous positive airway pressure (CPAP) on 24-hour blood and secretion catecholamines in urine plasma, we investigated changes urinary plasma concentrations epinephrine (E) norepinephrine (NE) 26 men with obstructive sleep apnea (OSA) without CPAP. Nasal CPAP resulted significant decreases daytime diastolic (from 86 ± 16 mmHg to 83 12 mmHg), nighttime 81 77 9 mmHg) systolic pressures 125 15 120 10 mmHg). There was no difference between patients or E level, but who received showed a decrease NE level 156 112 μg/14h 119 101 μg/14h) 143 91 μg/10h 65 μg/10h). The morning also decreased 371 181 pg/ml 273 148 pg/ml) (p<0.02), remained unchanged. were correlations PSG parameters reductions catecholamine levels induced by These findings suggest that OSA contributes, at least part, development systemic hypertension increasing sympathetic nervous activity.(Internal Medicine 37: 1009-1013, 1998)