Inhibition of platelet deposition by combined hirulog and aspirin in a rat carotid endarterectomy model

摘要: Abstract Purpose: Hirulog, a thrombin-specific inhibitor, has shown efficacy in reducing arterial thrombosis patients treated with aspirin who require angioplasty or have unstable angina. In this study, the effect of hirulog on deposition indium 111 -labeled platelets was assessed surgical model aspirin-treated rats undergoing carotid endarterectomy. Methods: Animals were randomly assigned to one five groups: control (no hirulog); alone (10 mg/kg); plus low-dose (0.2 mg/kg bolus followed by 0.5 mg/kg/hr); medium-dose (0.4 1.0 high-dose (0.6 1.5 mg/kg/hr). Hirulog infused before surgery and continued until termination experiment 30 minutes after Results: Platelet receiving reduced 19% ± 23% SE ( p = 0.26) compared controls. Deposition groups low-, medium-, decreased dose-dependent manner 37% 20% 0.048), 44% 0.061), 56% 13% 0.022), respectively. As dose increased, plasma levels activated partial thromboplastin time ratios (final:initial) also increased manner. The mean ranged from 0.74 0.08 μg/ml group 2.55 group, corresponding 0.12 0.001) 3.3 0.63 0.001). Bleeding easily controlled local hemostatic measures for all experimental groups. Conclusion: causes significant decrease In=labeled platelet subjected microsurgical endarterectomy at doses that allow hemostasis be established. (J VASC SURG 1995;21:492-8.)