Subcellular localization of indium-111 in indium-111-labeled platelets.

摘要: Human platelets labeled with (111In)oxine have been suggested for use in platelet kinetic studies, thrombus localizatin, detection of atheroscerotic lesions, and other scintigraphic techniques. To demonstrate the subcellular localization indium-111 platelets. Researchers did fractionation measured amount localized major components. were disrupted by nitrogen cavitation. The cellular material was fractionated on sucrose density gradients. When fractions analyzed, more than 70% located cytoplasmic pool Chromatography Sephadex G-100 aliquots cytosol showed that most associated components approximately 46,000 daltons. This demonstrated human is predominantly