Quantitation of Platelet Consumption in Health and Disease

摘要: The cloning of platelet receptors (glycoproteins) by recombinant-DNA technology and blocking the receptor functions monoclonal antibodies, consumption in health diseases is being understood at a molecular level. survival times healthy volunteers patients were determined with three markers: 51Cr-disodium chromate ACD-plasma, 111In-oxine ACD-saline 111In-tropolone ACD-plasma media. Difference found between 51Cr lllIn labels can be attributed to variation localization label on subcellular components renal handling after release. mean time was slightly longer than 111In showed sex difference not seen 111In-oxine. Protein bound plasma lower remained constant throughout study. Plasma increased correction subtraction free from blood radioactivity necessary. Both In-markers gave similar biodistribution; elaborate labeling no measurable advantage. contribution platelets clotting factors thrombosis cardiovascular diseases, prostheses effect platelet-inhibitors, anticoagulants plasminogen-activators dynamics organization adherent thrombus, had been evaluated several radiolabeled tracers. processes, phagocytosis, fragmentation could quantitatively radiolabeling, kinetics, imaging gamma camera, flow-cytometry autoradiography.