Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N^1-acetyltransferase
作者： Räsänen T.-L. , Alhonen L. , Sinervirta R. , Uimari A. , Kaasinen K.
DOI: 10.1080/00365520310003273
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摘要: Background: The male antifertility agent gossypol has been reported to induce spermidine/spermine N 1 -acetyltransferase (SSAT) in canine prostate cells. As SSAT is the rate-controlling enzyme catabolism of polyamines and involved development acute pancreatitis a recent transgenic rat model, we exposed normal rats over-expressing evaluate its effect on pancreatic polyamine metabolism organ integrity. Methods: Pancreatic activity, pools, histology plasma ! -amylase activity were determined after different doses gossypol. Results: Gossypol increased putrescine decreased spermidine spermine pools accompanied by tissue oedema significantly elevated amylase activity. In rats, drug strikingly induced SSAT, profoundly depleted higher caused distinct pancreatitis. combination at harmless pancreas wit...
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