Development of the diencephalon in the rat. II. Correlation of the embryonic development of the hypothalamus with the time of origin of its neurons.

摘要: The development of the nuclei hypothalamus was examined in normal and X-irradiated embryos from day 13 (E13) to before birth (E22). diencephalic neuroepithelium subdivided into three lobes (dorsal, medial, ventral) two lobules (superior inferior). is derived ventral lobe inferior lobule. neuroepithelial generates neurons most early arising hypothalamic structures, including those lateral tier associated with medial forebrain bundle, heterogeneous intermediate nuclei. A specialized region lining diamond shaped ventricle produces neurohypophysial magnocellular neurons; paraventricular nucleus remain at this site, whereas supraoptic could be traced migrating laterally. late hypophysiotropic area posterior are components lobule: dorsomedial ventromedial apparently a shared matrix main portion lobule; tuberomammillary-arcuate complex its posteroventral recess. triple-decked sequentially produced mammillary system may arise separate sites. autoradiographic results previous study (Altman Bayer, '78a) showed that structural functional heterogeneity mature paralleled by cytogenetic heterochronicity; present embryonic observations indicate many distinguishable mosaic