Pathogenetic and therapeutic applications of microRNAs in major depressive disorder.
作者： Yogesh Dwivedi
DOI: 10.1016/J.PNPBP.2015.02.003
关键词:
摘要: As a class of noncoding RNAs, microRNAs (miRNAs) regulate gene expression by inhibiting translation messenger RNAs. These miRNAs have been shown to play critical role in higher brain functioning and actively participate synaptic plasticity. Pre-clinical evidence demonstrates that is differentially altered during stress. On the other hand, depressed individuals show marked changes miRNA brain. MiRNAs are also target antidepressants electroconvulsive therapy. Moreover, these present circulating blood can be easily detected. Profiling plasma/serum provides determination used as possible diagnostic therapeutic tool. In this review article, aspects critically reviewed etiopathogenesis implications context major depressive disorder discussed.
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