Neuropeptide Y (NPY) gene: impact on emotional processing and treatment response in anxious depression

摘要: Neuropeptide Y (NPY) has been found to play a role in the pathomechanism of both anxiety and depression. Thus, NPY is promising candidate investigation clinical phenotype "anxious depression". Five gene variants were investigated for an influence on antidepressant treatment response sample 256 patients with Additionally, impact amygdala activation during facial emotion processing was analyzed subsample 35 depressed patients. Particularly anxious depression, less active rs16147 -399C allele conferred slow after 2weeks failure achieve remission four weeks treatment. The C further associated stronger bilateral threatening faces allele-dose fashion. present results point towards possible functional variation potentially conveyed by altered emotional processing.