Pro-apoptosis effects of protocatechuic acid in the early stage of infectious bursal disease virus infection

摘要: Abstract Infectious bursal disease virus (IBDV) is a very important small RNA in the family of Birnaviridae, which can cause severe immunosuppressive effects and pathological damages young chickens. It replicate lymphocytes impede growth development B cells, finally causing apoptosis. Previous results have shown that protocatechuic acid (PCA) as an phenolic compound could effectively improve survival rate chickens infected with IBDV. The current study aimed to explore how PCA influenced pathogenesis IBDV, especially lymphocyte apoptosis process IBDV infection. showed alleviate changes at early stage invasion. Moreover, for tissue section samples was largely elevated by using terminal dexynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) method while ratio also increased flow cytometry infection vivo. Meanwhile, promote non-lymphocyte vitro. Further displayed potential mechanisms mainly relied on regulation expressions pro-apoptotic protein Bax anti-apoptotic Bcl-2, thus speeding up IBDV-infected cell preventing PI3K/Akt NF kappa signal pathways might play role promoting after Overall, potent antiviral drug precursor expected be applied poultry industry substitute clinical application.