Metabolic Basis for the Diabetogenic Action of Growth Hormone in the Obese (ob/ob) Mouse*

摘要: The ob/ob mouse responds predictably to chronic treatment with large doses of pituitary GH marked hyperglycemia and decreased glucose tolerance. purpose the present study was characterize metabolic alterations produced by that lead this diabetogenic response in pb/ob order determine whether animal might serve as a useful model for cellular mechanisms involved action GH. Female mice were treated sc 3 days either saline or 200 μg/day Scarboxymethylated human (RCM-hGH), derivative lacking significant growth-promoting insulin-like activities. Six hours before start experiment, animals given injection 2 μg dexamethasone deprived food. RCM-hGH increases fasting blood plasma insulin concentrations, but had no effect on glucagon serum insulinlike growth factor I levels. It liver glycogen l...