Insulin, proinsulin, glucagon and gastrin in pancreatic tumors and in plasma of patients with organic hyperinsulinism.

摘要: Insulin, proinsulin, glucagon and gastrin were determined in extracts of tumors 27 patients with pancreatic islet cell neoplasia pancreas, one patient nesidioblastosis, uninvolved portions the pancreas 11 tumor 15 control pancreases. Mean insulin concentration solitary adenomas adenomatosis was higher than pancreases; however, all but 1 neoplastic tissue lower assuming volume is 1% pancreas. The percentage proinsulin elevated 52% tumors. Adenoma content correlated increments plasma after tolbutamide administration. Insulin concentrations by not suppressed. Fasting carcinoma some whom had multiple endocrine adenomatosis. mean Elevated found adenomas. data indicate: 1) insulin-secreting have decreased storage capacity for insulin, 2) may be due to store conversion as well, 3) stimulates exaggerated release a relatively constant fraction stored 4) contain excess amounts hormones addition 5) organic hyperinsulinism indicate malignancy, microadenomatosis or adenoma syndrome, 6) chronic hypoglycemia do suppress