Use of a GnRH agonist to suppress testosterone in wild male Hawaiian monk seals (Monachus schauinslandi).

摘要: Abstract A gonadotropin-releasing hormone (GnRH) agonist, d -Trp 6 -LHRH, was evaluated for its effectiveness in reducing circulating testosterone concentrations wild Hawaiian monk seals ( Monachus schauinslandi ). Twenty-eight adult male were randomly divided into three groups: 10 captured and treated with 7.5 mg of the GnRH 9 but did not receive near end study to serve as handling controls. Blood samples taken from all 28 seals. From 14 58 days after initial capture, 8 untreated recaptured a second sample blood taken. For comparison, also collected 4 captive during same months field study. In group, agonist induced significant decline mean concentrations, 1.01 ng/ml (first sample) 0.21 (second sample, approximately 38 later). first statistically indistinguishable (1.11 vs 1.16 ng/ml). The concentration group control (1.16 0.82 Also, four different that (1.38 1.11 These results suggest (1) suppresses production seals, (2) single does affect their levels, (3) appear be consistent Further evaluation this is necessary before it used management endangered species, these may useful tool mortality aggression related reproduction mating behavior.