Method for producing microspheres loaded with drugs and microspheres loaded with drugs produced thereby
作者： Hong Kee Sah
DOI:
关键词:
摘要: The present invention relates to a method for producing polymeric microspheres loaded with drugs and produced thereby, specifically drugs, the comprising steps of a) adding dispersion phase containing high molecular compound, drug, water-insoluble organic solvent produce an O/W (oil-in-water) type or 0/0 (oil-in-oil) emulsion, W/O (water-in-oil) which is prepared by emulsifying aqueous solution, in drug dissolved, solvent, compound W/O/W (water-in-oil-in- water) emulsion; b) ammonia solution emulsion step convert water- insoluble into water-soluble solvents, thereby. According invention, desired can be simply small amount water short period time.
lens.org 参考文章(18)
Hyeok Lee, Jeong Hwa Yang, Jung Ju Kim, Ham Yong Park, Polymeric microparticulates for sustained release of drug and their preparation methods ,(2003)
Toshio Yanaki, Michihiro Yamaguchi, Takufumi Kurosawa, Yuko Yamada, Kenzo Ito, Katsunori Yoshida, O/W/O type multiple emulsion and method of preparing the same ,(1996)
Johannes Tack, Georg Rossling, Celal Albayrak, Reinhard Schmitz, Process for the production of morphologically uniform microcapsules and microcapsules that are produced according to this process ,(2001)
Yasuaki Ogawa, Toshio Yoshioka, Hiroaki Okada, Sustained release microcapsule for water soluble drug ,(1989)
Jeffrey S Seitzinger, Pratibhash Chattopadhyay, Boris Y Shekunov, Method and apparatus for continuous particle production using supercritical fluid ,(2004)
Pele Chong, Michel H. Klein, Kenneth K. Sokoll, Biodegradable targetable microparticle delivery system ,(1997)
Jeffrey S. Seitzinger, Pratibhash Chattopadhyay, Boris Y. Shekunov, Method of forming particles ,(2004)
Motokazu Iwata, James W. Mcginity, Preparation and uses of multi-phase microspheres ,(1992)
Thomas R. Tice, Donald R. Cowsar, Danny H. Lewis, Lee R. Beck, Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents ,(1983)
John Barackman, Manmohan Singh, Gary S. Ott, Jina Kazzaz, Derek O'hagan, Microparticles with adsorbent surfaces, methods of making same, and uses thereof ,(1999)