Carbomethoxydifluoromethylation of enol acetates with methyl (chlorosulfonyl)difluoroacetate using visible-light photoredox catalysis. Synthesis of 2,2-difluoro-γ-ketoesters
作者： Charles S. Thomoson , William R. Dolbier
DOI: 10.1016/J.JFLUCHEM.2015.07.018
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摘要: Abstract In a visible light, room temperature photoredox catalytic process using 0.5 mol% of Ir[(dF(CF 3 )ppy) 2 (dtbbpy)]PF 6 catalyst, general method for attaching carbomethoxydifluoromethyl group to the alpha position ketone, reaction methyl (chlorosulfonyl)difluoroacetate (MCDA) with enol acetates, is reported. This allows synthesis variety 2,2-difluoro-γ-ketoesters in moderate very good yields.
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