Lignocaine kinetics in cardiac patients and aged subjects.

摘要: 1 The pharmacokinetics following long term intravenous infusion of lignocaine to cardiac patients have been examined. 2 Plasma levels and half-lives monoethylglycinexylidide (MEGX) showed wide inter-patient variability. 3 Toxicity reactions therapy were associated with elevated and/or MEGX plasma levels. 4 In a separate study the effect age on was examined using bolus doses (50 mg) drug young aged subjects. 5 Elderly subjects had significantly longer for compared younger individuals although no change in clearance occurred. 6 appeared distribute differently as reflected by increased apparent volumes distribution. 7 24 h urinary recovery major metabolite (total 4-hydroxyxylidine) significant reduction elderly when young. 8 clinical significance these studies respect has discussed.