Micronuclei, reproduction and child health.

摘要: Abstract The current review looks for relationships between results from biomarker studies with micronucleus and health effects related to reproduction children. In adults, an age increase in MN is well known as associations environmental exposures especially air pollution traffic smoking. Literature searches PubMED SCOPUS were performed the following keywords reproduction, children, micronuclei, effects. total 162 identified keyword Concerning children exposures, titles abstracts of a publications screened language, inclusion data selected according study selection chart. 9 included health, 21 12 buccal cells lymphocytes. read tables if on controls was available. frequencies collected peripheral blood lymphocytes (PBLs), reticulocytes or (BC) reported Mean ± SD Median (IQR). frequency Ratio, MRi, corresponding mean persons divided by control stated publication calculated us publication, where possible. Our systematic analysis revealed number positive marker increased risk relation child health. majority concerns maternal newborn exposure. Exposure monitoring also school however most often not MRis are found ranges 1 5.5 around 2. As far exposure concerned, range 0.9 5.5, 1.3–4.9 1.5 2.5 cells, except two no differences cases controls. Only one available MRi calculation value 2.3. These supporting relevant However, mostly small different protocol leaving out possibility metanalyses even statistical comparisons among studies. actual elevated MNs waits large cohort pooled datasets measured adults. Introduction non invasive alternative increasing standardised protocols recommended enable comparative metaanalyses.