Maternal vitamin A or β-carotene supplementation in lactating bangladeshi women benefits mothers and infants but does not prevent subclinical deficiency

摘要: The effects of maternal postpartum vitamin A or beta-carotene supplementation on and infant serum retinol concentrations, modified relative dose-response (MRDR) ratios breast milk concentrations were assessed during a community-based trial in Matlab, Bangladesh. At 1-3 wk postpartum, women randomly assigned to receive either (1) single dose 200,000 international units [60,000 equivalents (RE)] followed by daily placebos (n = 74), (2) doses [7.8 mg (1300 RE)] 73) (3) until 9 mo postpartum. Compared placebos, resulted lower MRDR (i.e., increased liver stores) higher at 3 mo, but these improvements not sustained. acted more slowly, resulting than the placebo group only mo. Irrespective treatment group, over 50% produced with low ( /=0. 06. We conclude that while both interventions beneficial, neither was sufficient correct underlying subclinical deficiency nor bring their infants into adequate status.