Repurposing Drugs to Fight Hepatic Malaria Parasites

摘要: Malaria remains one of the most prevalent infectious diseases worldwide, primarily affecting some vulnerable populations around globe. Despite achievements in treatment this devastating disease, there is still an urgent need for discovery new drugs that tackle infection by Plasmodium parasites. However, de novo drug development a costly and time-consuming process. An alternative strategy to evaluate anti-plasmodial activity compounds are already approved other purposes, approach known as repurposing. Here, we will review efforts assess existing drugs, with emphasis on obligatory clinically silent liver stage infection. We also current knowledge classes might be therapeutically relevant against context communicable regions where malaria endemic. Repositioning may constitute faster solution gap prophylactic therapeutic act parasites, overall contributing global effort eradication.