Estimating the Number of Persons Who Inject Drugs in the United States by Meta-Analysis to Calculate National Rates of HIV and Hepatitis C Virus Infections

摘要: Background: Injection drug use provides an efficient mechanism for transmitting bloodborne viruses, including human immunodeficiency virus (HIV) and hepatitis C (HCV). Effective targeting of resources prevention HIV HCV infection among persons who inject drugs (PWID) is based on knowledge the population size disparity in disease burden PWID. This study estimated number PWID United States to calculate rates infection. Methods: We conducted meta-analysis using data from 4 national probability surveys that measured lifetime (3 surveys) or past-year injection estimate proportion has injected drugs. then applied these proportions census produce estimates. To by calculating we used estimates as denominators surveillance survey data, respectively, numerators. calculated gender-, age-, race/ethnicity. Results: Lifetime comprised 2.6% (95% confidence interval: 1.8%–3.3%) U.S. aged 13 years older, representing approximately 6,612,488 (range: 4,583,188–8,641,788) 2011. The was 0.30% 0.19 %–0.41%) 774,434 494,605–1,054,263). Among PWID, 2011 diagnosis rate 55 per 100,000 PWID; living with a 2010 2,147 43,126 Conclusion: Estimates are important program planning addressing health inequities.