New and Revised Concepts in Multidrug Resistance

摘要: Drug resistance resulting from the outward efflux of anticancer agents by ATP binding cassette (ABC) transporters such as P-glycoprotein (P-gp) has been well described in vitro laboratory models. The extent to which multidrug are responsible for clinical drug more difficult determine. In one sense, P-gp can be viewed a molecular target that was tested clinic before there an adequate understanding diseases were best study, and inhibitors had identified. We now recognize several factors may have impeded results trials testing modulators. First, either not sufficiently potent or required areduction dose. Alternatively, presence other ABC transporters, resistance-associated protein (MRP1) half-transporter ABCG2, confounded results. A single-nucleotide polymorphism (SNP) limits expression could prevent inhibitor therapy benefiting patients, increase toxicity well. goal this chapter is evaluate new directions study resistance, offering fresh approaches fundamental question asks whether important targets development.