The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells.
作者： Monika Hitzl , Siegfried Drescher , Heiko van der Kuip , Elke Schäffeler , Joachim Fischer
DOI: 10.1097/00008571-200106000-00003
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摘要: P-glycoprotein (PGP) is a membrane protein which determines drug disposition in humans (eg digoxin). It is also expressed in various leukocyte lineages with highest expression in CD56+ natural killer cells. Recently, a polymorphism in exon 26 (C3435T) of this gene was shown to correlate with intestinal PGP expression and function in humans. Carriers homozygous for this polymorphism (TT) showed more than two-fold lower PGP expression and higher digoxin plasma concentrations compared to the CC group. However, it is not …
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sci-hub.se 参考文章(17)
Michael M. Gottesman, Suresh V. Ambudkar, Marilyn M. Cornwell, Ira Pastan, Ursula A. Germann, Multidrug Resistance Transporter Springer, Boston, MA. pp. 243- 257 ,(1996) , 10.1007/978-1-4613-1143-0_13
Alistair C Jones, Jehannine Austin, Nancy Hansen, Bastiaan Hoogendoorn, Peter J Oefner, Jeremy P Cheadle, Michael C O’Donovan, Optimal Temperature Selection for Mutation Detection by Denaturing HPLC and Comparison to Single-Stranded Conformation Polymorphism and Heteroduplex Analysis Clinical Chemistry. ,vol. 45, pp. 1133- 1140 ,(1999) , 10.1093/CLINCHEM/45.8.1133
F. Thiebaut, T. Tsuruo, H. Hamada, M. M. Gottesman, I. Pastan, M. C. Willingham, Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 7735- 7738 ,(1987) , 10.1073/PNAS.84.21.7735
A. Sparreboom, J. van Asperen, U. Mayer, A. H. Schinkel, J. W. Smit, D. K. F. Meijer, P. Borst, W. J. Nooijen, J. H. Beijnen, O. van Tellingen, Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 2031- 2035 ,(1997) , 10.1073/PNAS.94.5.2031
M.B. LUCIA, R. CAUDA, A.L. LANDAY, W. MALORNI, G. DONELLI, L. ORTONA, Transmembrane P-glycoprotein (P-gp/P-170) in HIV infection: analysis of lymphocyte surface expression and drug-unrelated function. AIDS Research and Human Retroviruses. ,vol. 11, pp. 893- 901 ,(1995) , 10.1089/AID.1995.11.893
Kenneth S. Lown, Robert R. Mayo, Alan B. Leichtman, Hsiu-ling Hsiao, D. Kim Turgeon, Phyllissa Schmiedlin-Ren, Morton B. Brown, Wensheng Guo, Stephen J. Rossi, Leslie Z. Benet, Paul B. Watkins, Role of intestinal P‐glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine Clinical Pharmacology & Therapeutics. ,vol. 62, pp. 248- 260 ,(1997) , 10.1016/S0009-9236(97)90027-8
Bernd Greiner, Michel Eichelbaum, Peter Fritz, Hans-Peter Kreichgauer, Oliver von Richter, Johannes Zundler, Heyo K. Kroemer, The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin Journal of Clinical Investigation. ,vol. 104, pp. 147- 153 ,(1999) , 10.1172/JCI6663
Walter T. Klimecki, Charles W. Taylor, William S. Dalton, Inhibition of cell-mediated cytolysis and P-glycoprotein function in natural killer cells by verapamil isomers and cyclosporine a analogs Journal of Clinical Immunology. ,vol. 15, pp. 152- 158 ,(1995) , 10.1007/BF01543107
M.F. Fromm, P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs. principles and practice of constraint programming. ,vol. 38, pp. 69- 74 ,(2000) , 10.5414/CPP38069
S. Hoffmeyer, O. Burk, O. von Richter, H. P. Arnold, J. Brockmoller, A. Johne, I. Cascorbi, T. Gerloff, I. Roots, M. Eichelbaum, U. Brinkmann, Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 3473- 3478 ,(2000) , 10.1073/PNAS.97.7.3473