Polymorphism in the P-glycoprotein drug transporter MDR1 gene in renal transplant patients treated with cyclosporin A in a Polish population.
作者： Monika Białecka , Marek Droździk , Tadeusz Sulikowski , Katarzyna Kotrych , Leszek Domański
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摘要: P-glycoprotein (P-gp), the product of MDR1 gene, is a protein which mediates transmembrane transport great number xenobiotics including cyclosporin A used as an immunosuppressive drug in patients with allogenic kidney grafts. The P-gp activity and expression dependent on gene polymorphism position C3435T exon 26. In this study, was analyzed 116 graft treated Aand 144 randomly selected healthy individuals. prevalence genotypes 3435CC, 3435CT, 3435TT were also compared after both acute chronic rejection (48 76 rejection) control groups (respectively 139 112). results study demonstrated that allelic frequency genotype distribution similar all evaluated groups. It revealed not predisposing factor for terminal failure leading to renal transplantation. Moreover, evaluation will probably be useful characterization at increased risk rejection.
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