677C>T and 1298A>C MTHFR polymorphisms affect methotrexate treatment outcome in rheumatoid arthritis.
作者： Mateusz Kurzawski , Andrzej Pawlik , Krzysztof Safranow , Magdalena Herczynska , Marek Drozdzik
DOI: 10.2217/14622416.8.11.1551
关键词:
摘要: Introduction: Methotrexate (MTX), widely used in the treatment of rheumatoid arthritis (RA), inhibits dihydrofolate reductase and folate-dependent enzymes. Methylenetetrahydrofolate (MTHFR) is involved folate metabolism has been shown to be polymorphic, affecting enzyme activity. Methods: To examine association between 677C>T 1298A>C MTHFR polymorphisms MTX efficacy RA, a total 174 RA patients, treated with plus methylprednisone 4 mg folic acid 5 mg were analyzed. Results: In univariate regression analysis model, 677T allele was associated significantly higher frequency remission, whereas case 1298C allele, tendency for remission rate observed. multivariate analysis, presence both alleles an increased remission. Conclusion: The results our study suggest that may r...
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