Genetic Predisposition and Renal Allograft Failure

摘要: Renal allograft rejection or dysfunction often results in graft failure, and remains the major obstacle success of renal transplantation. Various immunological nonimmunological factors are involved rejection. In addition to human leukocyte antigen loci, several genetically controlled molecules have been identified recent years as playing important roles process Genetic variants genes encoding different T-helper (Th) type 1 Th2 cytokines, chemokines their receptors, growth factors, renin-angiotensin system, enzymes homocysteine pathway, proteins acting substrates immunosuppressive drugs impact on engraftment highlight concept genetic predisposition This review evaluates specific functional with an emphasis latest methodologies available for genotyping, appropriate strategies enable them become a tool predictive individualized medicine ensure better transplant outcome.