An Essential Role for the Transcription Factor Runx1 in T Cell Maturation

摘要: The transcription factor Runx1 has essential roles throughout hematopoiesis. Here, we demonstrate that is critical for T cell maturation. Peripheral naive CD4+ cells from CD4-cre cKO mice are phenotypically and functionally immature as shown by decreased production of TNF-α upon TCR stimulation. loss peripheral in not due to defects homeostasis or expression IL-7Rα, transgenic IL-7Rα does rescue the cells. Rather, Runx1-deficient eliminated periphery activation fixation classical complement pathway. In thymus, there a severe block all aspects intrathymic maturation, although both positive negative selection unaltered. Thus, leads earliest characterized post-positive maturation CD4