Comparing the protective effects of three sulfur compounds against acrylonitrile-induced acute toxicity in CYP2E1-induced rats.

摘要: Cytochrome P450 2E1 (CYP2E1) can be induced by diabetes mellitus, nonalcoholic liver disease, and obesity. This study assessed the protective effects of three sulfur compounds, namely phenethyl isothiocyanate (PEITC), dimethyl trisulfide (DMTS), sodium thiosulfate (STS), on acrylonitrile (ACN)-induced acute toxicity in rats enriched with CYP2E1. PEITC DMTS were administered intragastrically (i.g.), whereas STS was injected intraperitoneally (i.p.) at an identical dose 0.5 mmol/kg for 3 days acetone-pretreated before ACN (90 mg/kg) injection (i.p.). Acetone-treated that expressed high levels CYP2E1 more susceptible to ACN-induced toxicity. The compounds reduced rate convulsions loss righting reflex ACN-exposed CYP2E1-induced rats; also increased survival rates. inhibited hepatic activity protected cerebral cytochrome c oxidase (CcOx) activities CYP2E1-enriched CcOx activity. attenuated oxidative injury reducing malondialdehyde (MDA) increasing glutathione content brain. only MDA levels, did not exhibit any antioxidant effects. Collectively, provided superior against activity, followed DMTS; limited might considered as promising chemopreventive agents vulnerable subpopulations