The Issue of Studies Evaluating Biomarkers Which Predict Outcome after Pemetrexed-Based Chemotherapy in Malignant Pleural Mesothelioma

Takeshi Hanagiri, Hidetaka Uramoto, Hidehiko Shimokawa, Takamitsu Onitsuka, TS, DHFR and GARFT Expression in Non-squamous Cell Carcinoma of NSCLC and Malignant Pleural Mesothelioma Patients Treated with Pemetrexed Anticancer Research. ,vol. 30, pp. 4309- 4315 ,(2010)

J E Nutt, A R A Razak, K O'Toole, F Black, A E Quinn, A H Calvert, E R Plummer, J Lunec, The role of folate receptor alpha (FRα) in the response of malignant pleural mesothelioma to pemetrexed-containing chemotherapy. British Journal of Cancer. ,vol. 102, pp. 553- 560 ,(2010) , 10.1038/SJ.BJC.6605501

Fabian Mairinger, Claudia Vollbrecht, Iris Halbwedl, Martina Hatz, Elvira Stacher, Christian Gülly, Franz Quehenberger, Susann Stephan-Falkenau, Jens Kollmeier, Andreas Roth, Thomas Mairinger, Helmut Popper, Reduced folate carrier and folylpolyglutamate synthetase, but not thymidylate synthase predict survival in pemetrexed-treated patients suffering from malignant pleural mesothelioma. Journal of Thoracic Oncology. ,vol. 8, pp. 644- 653 ,(2013) , 10.1097/JTO.0B013E318287C224

Daniel E. Schwed Lustgarten, Charuhas Deshpande, Charu Aggarwal, Liang-Chuan Wang, Vassiliki Saloura, Anil Vachani, Li-Ping Wang, Leslie Litzky, Michael Feldman, Jeanette Creaney, Anna K. Nowak, Corey Langer, Simona Inghilleri, Giulia Stella, Steven M. Albelda, Thymidylate Synthase and Folyl-Polyglutamate Synthase Are Not Clinically Useful Markers of Response to Pemetrexed in Patients with Malignant Pleural Mesothelioma Journal of Thoracic Oncology. ,vol. 8, pp. 469- 477 ,(2013) , 10.1097/JTO.0B013E318283DA3E

Cindy Tran, Xian Lu, Murry W. Wynes, Thomas C. Gauler, Jeremias Wohlschlaeger, Dirk Theegarten, Volker Neumann, Rodrigo Hepp, Stefan Welter, Georgios Stamatis, Andrea Tannapfel, Martin Schuler, Wilfried E. Eberhardt, Fred R. Hirsch, Folylpoly-Glutamate Synthetase Expression Is Associated with Tumor Response and Outcome from Pemetrexed-Based Chemotherapy in Malignant Pleural Mesothelioma Journal of Thoracic Oncology. ,vol. 7, pp. 1440- 1448 ,(2012) , 10.1097/JTO.0B013E318260DEAA

Yehuda G. Assaraf, Molecular basis of antifolate resistance. Cancer and Metastasis Reviews. ,vol. 26, pp. 153- 181 ,(2007) , 10.1007/S10555-007-9049-Z

Paolo Andrea Zucali, Elisa Giovannetti, Annarita Destro, Manlio Mencoboni, Giovanni Luca Ceresoli, Letizia Gianoncelli, Elena Lorenzi, Fabio De Vincenzo, Matteo Simonelli, Matteo Perrino, Andrea Bruzzone, Erik Thunnissen, Gianni Tunesi, Laura Giordano, Massimo Roncalli, Godefridus J. Peters, Armando Santoro, Thymidylate Synthase and Excision Repair Cross-Complementing Group-1 as Predictors of Responsiveness in Mesothelioma Patients Treated with Pemetrexed/Carboplatin Clinical Cancer Research. ,vol. 17, pp. 2581- 2590 ,(2011) , 10.1158/1078-0432.CCR-10-2873

Luisella Righi, Mauro G. Papotti, Paolo Ceppi, Andrea Billè, Elisa Bacillo, Luca Molinaro, Enrico Ruffini, Giorgio V. Scagliotti, Giovanni Selvaggi, Thymidylate Synthase But Not Excision Repair Cross-Complementation Group 1 Tumor Expression Predicts Outcome in Patients With Malignant Pleural Mesothelioma Treated With Pemetrexed-Based Chemotherapy Journal of Clinical Oncology. ,vol. 28, pp. 1534- 1539 ,(2010) , 10.1200/JCO.2009.25.9275

Stephen A Bustin, Vladimir Benes, Jeremy A Garson, Jan Hellemans, Jim Huggett, Mikael Kubista, Reinhold Mueller, Tania Nolan, Michael W Pfaffl, Gregory L Shipley, Jo Vandesompele, Carl T Wittwer, The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments Clinical Chemistry. ,vol. 55, pp. 611- 622 ,(2009) , 10.1373/CLINCHEM.2008.112797