Thymidylate Synthase But Not Excision Repair Cross-Complementation Group 1 Tumor Expression Predicts Outcome in Patients With Malignant Pleural Mesothelioma Treated With Pemetrexed-Based Chemotherapy
作者： Luisella Righi , Mauro G. Papotti , Paolo Ceppi , Andrea Billè , Elisa Bacillo
关键词: Pemetrexed 、 Pathology 、 Mesothelioma 、 Gastroenterology 、 Internal medicine 、 Hazard ratio 、 ERCC1 、 Pleural Neoplasm 、 Chemotherapy 、 Pleural disease 、 Medicine 、 Thymidylate synthase
摘要: Purpose The relationship between thymidylate synthase (TS) expression and outcome in patients with malignant pleural mesothelioma (MPM) treated pemetrexed (P) was retrospectively evaluated. Patients Methods Sixty histologically confirmed MPM previously P platinum (45 of 60) or as single agent (15 were considered. Eighty-one control not P-treated also TS excision repair cross-complementation group 1 (ERCC1) gene levels evaluated by real-time polymerase chain reaction immunohistochemistry using the H-score. Results Median H-score value 90 (range, 5 to 240). A significant correlation low protein longer time progression (TTP; 17.9 v 7.9 months; hazard ratio [HR], 2.05, 95% CI, 1.19 3.77; = .02) overall survival (OS; 30 16.7 HR, 2.38; 1.15 4.91; .019) found when divided according median Conv...
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