Differences in Therapeutic Indexes of Combination Metronomic Chemotherapy and an Anti-VEGFR-2 Antibody in Multidrug-resistant Human Breast Cancer Xenografts

作者: Giannoula Klement , Daniel Hicklin , Shan Man , Ping Huang , Robert S. Kerbel

DOI:

关键词:

摘要: … The rationale for this combination is that anti-VEGFR-2- or … or in combination with a second drug such as anti-VEGFR-2 … drugs are used in combination with the antiangiogenic, VEGFR-2-…

参考文章(36)
W. Liu, S. A. Ahmad, N. Reinmuth, R. M. Shaheen, Y. D. Jung, F. Fan, L. M. Ellis, Endothelial cell survival and apoptosis in the tumor vasculature. Apoptosis. ,vol. 5, pp. 323- 328 ,(2000) , 10.1023/A:1009679307513
Philipp le Coutre, Elena Tassi, Marileila Varella-Garcia, Rossella Barni, Luca Mologni, Gonçalo Cabrita, Edoardo Marchesi, Rosanna Supino, Carlo Gambacorti-Passerini, Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification. Blood. ,vol. 95, pp. 1758- 1766 ,(2000) , 10.1182/BLOOD.V95.5.1758.005A41_1758_1766
Judah Folkman, Philip Hahnfeldt, Lynn Hlatky, Cancer: looking outside the genome Nature Reviews Molecular Cell Biology. ,vol. 1, pp. 76- 79 ,(2000) , 10.1038/35036100
Ie-Ming Shih, Christopher Torrance, Lori J. Sokoll, Daniel W. Chan, Kenneth W. Kinzler, Bert Vogelstein, Assessing tumors in living animals through measurement of urinary beta-human chorionic gonadotropin. Nature Medicine. ,vol. 6, pp. 711- 714 ,(2000) , 10.1038/76299
François Xavier Mahon, Michael W. N. Deininger, Beate Schultheis, Jérome Chabrol, Josy Reiffers, John M. Goldman, Junia V. Melo, Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance Blood. ,vol. 96, pp. 1070- 1079 ,(2000) , 10.1182/BLOOD.V96.3.1070
Philippe Gros, Marie Azzaria, Jeffrey F. Lemontt, Increased mdr gene expression and decreased drug accumulation in multidrug-resistant human melanoma cells. Cancer Research. ,vol. 48, pp. 6348- 6353 ,(1988)
Thomas Boehm, Judah Folkman, Timothy Browder, Michael S. O'Reilly, Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance Nature. ,vol. 390, pp. 404- 407 ,(1997) , 10.1038/37126
Larry Witte, Daniel J. Hicklin, Zhenping Zhu, Bronislaw Pytowski, Helen Kotanides, Patricia Rockwell, Peter Böhlen, Monoclonal antibodies targeting the VEGF receptor-2 (Flk1/KDR) as an anti-angiogenic therapeutic strategy. Cancer and Metastasis Reviews. ,vol. 17, pp. 155- 161 ,(1998) , 10.1023/A:1006094117427
J D Hainsworth, H A Burris, J B Erland, M Thomas, F A Greco, Phase I trial of docetaxel administered by weekly infusion in patients with advanced refractory cancer. Journal of Clinical Oncology. ,vol. 16, pp. 2164- 2168 ,(1998) , 10.1200/JCO.1998.16.6.2164