Tick-borne rickettsioses, neglected emerging diseases in rural Senegal.

摘要: Background Rickettsioses are one of the most important causes systemic febrile illness among travelers from developed countries, but little is known about their incidence in indigenous populations, especially West Africa. Methodology/Principal Findings Overall seroprevalence evaluated by immunofluorescence using six rickettsial antigens (spotted fever and typhus group) rural populations two villages Sine-Saloum region Senegal was found to be 21.4% 51% for spotted group rickettsiae Dielmo Ndiop villages, respectively. We investigated role tick-borne as cause acute non-malarial diseases same villages. The DNA 204 blood samples 134 (62M 72F) patients negative malaria studied. extracted whole tested qPCR systems. Rickettsial nine patients, eight with Rickettsia felis (separately reported). For first time Africa, conorii diagnosed patient. also 2,767 Ixodid ticks collected regions (Niakhar Sine-Saloum) domestic animals (cows, sheep, goats, donkeys horses) identified five different pathogenic rickettsiae. following: aeschlimannii Hyalomma marginatum rufipes (51.3% 44.8% Niakhar region, respectively), truncatum (6% 6.8%) Rhipicephalus evertsi (0.5%, only Niakhar); R. c. Rh. e. (0.4%, Sine-Saloum); massiliae guilhoni (22.4%, sibirica mongolitimonae (13.5%, africae (0.7% 0.4% respectively) well annulatus (20%, Sine-Saloum). isolated strains H. truncatum: s. aeschlimannii. Conclusions/Significance We believe that together our previous data on high prevalence Amblyomma infection presented results distribution case Africa show population at risk other rickettsioses, which significant disease this area.