Heterogeneity of the action potential duration is required for sustained atrial fibrillation.

摘要: Atrial fibrillation (AF) is the most common cardiac arrhythmia and accounts for substantial morbidity mortality. Recently, we created a mouse model with spontaneous sustained AF caused by mutation in NaV1.5 channel (F1759A) that enhances persistent Na+ current, thereby enabling investigation of molecular mechanisms cause identification novel treatment strategies. The mice have regional heterogeneity action potential duration atria similar to observations patients AF. In these mice, found initiation persistence rotational reentrant arrhythmias, known as spiral waves or rotors, were dependent upon heterogeneity. centers rotors localized regions greatest duration. Pharmacologically attenuating reduced both pacing-induced Computer-based simulations also demonstrated sufficient generate manifest Taken together, findings suggest humans one mechanism which initiated reducing can lessen burden