Oxazolidinone compounds and compositions and methods related thereto

作者: Antonio Guglietta , Montserrat Cano , Albert Palomer

DOI:

关键词:

摘要: The invention provides new oxazolidinones of formula (I), where R1, R2, R3 and R4 are independently selected from hydrogen, F Cl; A is certain heterocycles optionally substituted; X O, S, NRs CR8Rg; Y SO, SO2, NO, NR11 CR11R12; n 0 1. also different processes for the preparation such compounds. Oxazolidinone compounds (I) active against Gram-positive some Gram-negative human veterinary pathogens with a weak monoamine oxidase (MAO) inhibitory activity. They useful treatment bacterial infections.

参考文章(9)
Daisy Pireh, Paul E. Wiedeman, Hana Kopecka, Steven W. Djuric, David J. Madar, Oxazolidinone antibacterial agents ,(2001)
A Mehta, SK Arora, B Das, A Ray, S Rudra, A Rattan, Oxazolidinone derivatives as antimicrobials ,(2002)
Uwe Saatmann, Ulrich Rester, Marcus Bauser, Hartmut Schirok, Swen Allerheiligen, Julia Strassburger, Elke Dittrich-Wengenroth, Stephan Siegel, Anja Buchmüller, Christoph Gerdes, Degenfeld Georges Von, Dieter Lang, Stefan Heitmeier, Mark Jean Gnoth, Michael Härter, Substituierte Oxazolidinone und ihre Verwendung ,(2008)
Shrikant V Gupte, Yati Chugh, Milind D Sindkhedkar, Mahesh V Patel, Milind C Shukla, Prasad K Deshpande, Ravindra D Yeole, Nitin Shetty, Souza Noel J De, Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them ,(2003)
Michael John Dupuis, Joseph Patrick Martin, John Thomas Herberg, Cotherapy with an oxazolidinone and a vitamin b ,(2003)
Alexander Straub, Joseph Pernerstorfer, Jens Pohlmann, Karl-Heinz Schlemmer, Elisabeth Perzborn, Susanne Rohrig, Thomas Lampe, Substituted oxazolidinones and their in the field of blood coagulation ,(2000)