A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia.

摘要: Superoxide anion and other oxygen-free radicals have been implicated in the pathogenesis of bronchopulmonary dysplasia. We tested hypothesis that a catalytic antioxidant metalloporphyrin AEOL 10113 can protect against hyperoxia-induced lung injury using fetal baboon model Fetal baboons were delivered by hysterotomy at 140 days gestation (term = 185 days) given 100% oxygen for 10 days. Morphometric analysis alveolar structure showed on alone had increased parenchymal mast cells eosinophils, tissue volume septal thickness, decreased surface area compared with animals as needed. Treatment (continuous intravenous infusion) during exposure partially reversed these oxygen-induced changes. Hyperoxia number neuroendocrine peripheral lung, which was preceded levels urine bombesin-like peptide 48 hours age. inhibited increases numbers cells. An increasing trend oxygenation index over time observed group but not mimetic-treated group. These results suggest might reduce risk pulmonary toxicity prematurely born infants.