Reduced Leptin Levels in Starvation Increase Susceptibility to Endotoxic Shock

摘要: Malnutrition compromises immune function, reducing resistance to infection. We examine whether the decrease in leptin induced by starvation increases susceptibility lipopolysaccharide (LPS)- and tumor necrosis factor (TNF)-induced lethality. In mice, fasting for 48 hours enhances sensitivity LPS. Decreasing fasting-induced fall administration markedly reduced Although decreases basal levels, LPS treatment increased same extent as fed animals. Fasting serum corticosterone; blunted this increase. decreased ability of increase restored corticosterone response Serum glucose levels were fasted mice a further decrease. Leptin affected neither nor that after fivefold greater TNF which was replacement. contrast, lower interferon-γ no differences interleukin-1β compared had effect on those cytokines. Furthermore, lethal itself, also reversed treatment. Thus, seems be protective both inhibiting induction toxicity.