Effects of aspirin and paracetamol on naloxone reversal of morphine-induced inhibition of gastrointestinal propulsion in mice.

摘要: In mice, morphine caused a dose-dependent slowing of the rate intestinal transit charcoal meal. This inhibitory effect was antagonised by naloxone. Pretreatment with single dose did not induce any detectable tolerance to action second given 4 h later. However, naloxone more effective in antagonising inhibition morphine-pretreated mice than saline-pretreated animals. either aspirin or paracetamol alter 4.5 antagonistic significantly augmented, though same extent as that pretreatment. When together pretreatment, resulting antagonism measured later higher induced pretreatment individual drugs. Furthermore, combined 20.0 mg/kg and 40.0 The present study indicates prostaglandins reduce on may interfere development tolerance.