The Whipple Riddle

摘要: Whipple disease (intestinal lipodystrophy) is a systemic disorder that involves not only the small bowel and lymph nodes but also liver, spleen, heart, brain, other organs. Histopathologically, characterized by ubiquitous macrophages give positive diastase-resistant PAS staining reaction. Although can be treated with antibiotics, its etiology remains one of unsolved riddles medicine, is, perhaps, until now. Clancy associates 1 recently reported in British Medical Journal cell wall-deficient form (CWD) an α-hemolytic Streptococcus was grown from prolonged monolayer culture node taken patient disease. Serological cross reactivity shown between organisms material within macrophages. In vitro studies as facultative intracellular parasite caused accumulation cells PASpositive material. Moreover, parenteral injection this CWD organism into